High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis?

Self-reactive T cells with low signalling capacity through the T-cell receptor were recently observed in the SKG mouse model of rheumatoid arthritis (RA) and have been linked to a spontaneous mutation in the ZAP-70 signal transduction molecule. Here we hypothesize that similar mechanisms also drive...

Descripción completa

Detalles Bibliográficos
Autores principales: Thomas, Ranjeny, Turner, Malcolm, Cope, Andrew P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575618/
https://www.ncbi.nlm.nih.gov/pubmed/18710589
http://dx.doi.org/10.1186/ar2446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575618/
https://www.ncbi.nlm.nih.gov/pubmed/18710589
http://dx.doi.org/10.1186/ar2446

Ejemplares similares