Ectopic expression of a truncated CD40L protein from synthetic post-transcriptionally capped RNA in dendritic cells induces high levels of IL-12 secretion

BACKGROUND: RNA transfection into dendritic cells (DCs) is widely used to achieve antigen expression as well as to modify DC properties. CD40L is expressed by activated T cells and interacts with CD40 receptors expressed on the surface of the DCs leading to Th1 polarization. Previous studies demonst...

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Detalles Bibliográficos
Autores principales: Tcherepanova, Irina Y, Adams, Melissa D, Feng, Xiaorong, Hinohara, Atsushi, Horvatinovich, Joe, Calderhead, David, Healey, Don, Nicolette, Charles A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576345/
https://www.ncbi.nlm.nih.gov/pubmed/18928538
http://dx.doi.org/10.1186/1471-2199-9-90

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576345/
https://www.ncbi.nlm.nih.gov/pubmed/18928538
http://dx.doi.org/10.1186/1471-2199-9-90

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