A practical synthesis of the (13)C/(15)N-labelled tripeptide N-formyl-Met-Leu-Phe, useful as a reference in solid-state NMR spectroscopy

A mild synthetic method for N-formyl-Met-Leu-Phe-OH (1) is described. After Fmoc solid phase peptide synthesis, on-bead formylation and HPLC purification, more than 30 mg of the fully (13)C/(15)N-labelled tripeptide 1 could be isolated in a typical batch. This peptide can be easily crystallised and...

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Detalles Bibliográficos
Autores principales: Breitung, Sven T, Lopez, Jakob J, Dürner, Gerd, Glaubitz, Clemens, Göbel, Michael W, Suhartono, Marcel
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2008
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577282/
https://www.ncbi.nlm.nih.gov/pubmed/18982075
http://dx.doi.org/10.3762/bjoc.4.35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577282/
https://www.ncbi.nlm.nih.gov/pubmed/18982075
http://dx.doi.org/10.3762/bjoc.4.35

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