Cargando…
Identification of the Xenopus DNA2 protein as a major nuclease for the 5′→3′ strand-specific processing of DNA ends
The first step of homology-dependent DNA double-strand break (DSB) repair is the 5′ strand-specific processing of DNA ends to generate 3′ single-strand tails. Despite extensive effort, the nuclease(s) that is directly responsible for the resection of 5′ strands in eukaryotic cells remains elusive. U...
Autores principales: | Liao, Shuren, Toczylowski, Thomas, Yan, Hong |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577336/ https://www.ncbi.nlm.nih.gov/pubmed/18820296 http://dx.doi.org/10.1093/nar/gkn616 |
Ejemplares similares
-
Mechanistic analysis of Xenopus EXO1's function in 5′-strand resection at DNA double-strand breaks
por: Liao, Shuren, et al.
Publicado: (2011) -
Analysis of MRE11's function in the 5′→3′ processing of DNA double-strand breaks
por: Liao, Shuren, et al.
Publicado: (2012) -
The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair
por: Liao, Shuren, et al.
Publicado: (2016) -
DNA double-strand breaks with 5′ adducts are efficiently channeled to the DNA2-mediated resection pathway
por: Tammaro, Margaret, et al.
Publicado: (2016) -
The N-terminus of RPA large subunit and its spatial position are important for the 5′->3′ resection of DNA double-strand breaks
por: Tammaro, Margaret, et al.
Publicado: (2015)