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TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

The role of tumor necrosis factor (TNF) as an immune mediator has long been appreciated but its function in the brain is still unclear. TNF receptor 1 (TNFR1) is expressed in most cell types, and can be activated by binding of either soluble TNF (solTNF) or transmembrane TNF (tmTNF), with a preferen...

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Detalles Bibliográficos
Autores principales: McCoy, Melissa K, Tansey, Malú G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577641/
https://www.ncbi.nlm.nih.gov/pubmed/18925972
http://dx.doi.org/10.1186/1742-2094-5-45