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A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

Maintaining the appropriate complement and content of lipids in cellular membranes is critical for normal neural function. Accumulating evidence suggests that even subtle perturbations in the lipid content of neurons and myelin can disrupt their function and may contribute to myelin and axonal degra...

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Detalles Bibliográficos
Autores principales: Wheeler, David, Bandaru, Veera Venkata Ratnam, Calabresi, Peter A., Nath, Avindra, Haughey, Norman J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577809/
https://www.ncbi.nlm.nih.gov/pubmed/18772223
http://dx.doi.org/10.1093/brain/awn190