Cargando…

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

Maintaining the appropriate complement and content of lipids in cellular membranes is critical for normal neural function. Accumulating evidence suggests that even subtle perturbations in the lipid content of neurons and myelin can disrupt their function and may contribute to myelin and axonal degra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wheeler, David, Bandaru, Veera Venkata Ratnam, Calabresi, Peter A., Nath, Avindra, Haughey, Norman J.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577809/ https://www.ncbi.nlm.nih.gov/pubmed/18772223 http://dx.doi.org/10.1093/brain/awn190

Ejemplares similares

Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum
por: Bandaru, Veera Venkata Ratnam, et al.
Publicado: (2014)

The Role of ATP-Binding Cassette Transporters in Neuro-Inflammation: Relevance for Bioactive Lipids
por: Kooij, Gijs, et al.
Publicado: (2012)

Demographic and clinical variables affecting mid‐ to late‐life trajectories of plasma ceramide and dihydroceramide species
por: Mielke, Michelle M., et al.
Publicado: (2015)

Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging
por: Mielke, Michelle M, et al.
Publicado: (2015)

Deficiency of a Niemann-Pick, Type C1-related Protein in Toxoplasma Is Associated with Multiple Lipidoses and Increased Pathogenicity
por: Lige, Bao, et al.
Publicado: (2011)

Reduced Creatine Kinase B Activity in Multiple Sclerosis Normal Appearing White Matter
por: Steen, Christel, et al.
Publicado: (2010)

Increased Perfusion in Normal Appearing White Matter in High Inflammatory Multiple Sclerosis Patients
por: Bester, Maxim, et al.
Publicado: (2015)

Abnormalities in normal-appearing white matter from which multiple sclerosis lesions arise
por: Elliott, Colm, et al.
Publicado: (2021)

White matter hyperintensities and normal-appearing white matter integrity in the aging brain
por: Maniega, Susana Muñoz, et al.
Publicado: (2015)

Use of a Glycolipid Inhibitor to Ameliorate Renal Cancer in a Mouse Model
por: Chatterjee, Subroto, et al.
Publicado: (2013)

Blood-Brain Barrier Permeability of Normal Appearing White Matter in Relapsing-Remitting Multiple Sclerosis
por: Lund, Henrik, et al.
Publicado: (2013)

Normal Appearing and Diffusely Abnormal White Matter in Patients with Multiple Sclerosis Assessed with Quantitative MR
por: West, Janne, et al.
Publicado: (2014)

Correction: Increased Perfusion in Normal Appearing White Matter in High Inflammatory Multiple Sclerosis Patients
por: Bester, Maxim, et al.
Publicado: (2015)

Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter
por: Miedema, Anneke, et al.
Publicado: (2022)

DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patients
por: Kular, Lara, et al.
Publicado: (2022)

Pathological ultrastructural alterations of myelinated axons in normal appearing white matter in progressive multiple sclerosis
por: Oost, Wendy, et al.
Publicado: (2023)

Abnormal blood–brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI()()
por: Cramer, S.P., et al.
Publicado: (2013)

Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier
por: Gallego-Delgado, Patricia, et al.
Publicado: (2020)

Magnetic susceptibility anisotropy in normal appearing white matter in multiple sclerosis from single-orientation acquisition
por: Sibgatulin, Renat, et al.
Publicado: (2022)

Increased Concentrations of Glutamate and Glutamine in Normal-Appearing White Matter of Patients with Multiple Sclerosis and Normal MR Imaging Brain Scans
por: Tisell, Anders, et al.
Publicado: (2013)

Association between hypertension and neurovascular inflammation in both normal-appearing white matter and white matter hyperintensities
por: Solé-Guardia, Gemma, et al.
Publicado: (2023)

Association between Change in Normal Appearing White Matter Metabolites and Intrathecal Inflammation in Natalizumab-Treated Multiple Sclerosis
por: Mellergård, Johan, et al.
Publicado: (2012)

Analysis of normal-appearing white matter of multiple sclerosis by tensor-based two-compartment model of water diffusion
por: Tachibana, Yasuhiko, et al.
Publicado: (2015)

Axonal damage in the making: Neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter()
por: Petzold, A., et al.
Publicado: (2011)

Lipid biochemical changes detected in normal appearing white matter of chronic multiple sclerosis by spectral coherent Raman imaging
por: Poon, K. W. C., et al.
Publicado: (2018)

Transcriptome analysis of normal-appearing white matter reveals cortisol- and disease-associated gene expression profiles in multiple sclerosis
por: Melief, Jeroen, et al.
Publicado: (2019)

Metabolic changes in normal appearing white matter in multiple sclerosis patients using multivoxel magnetic resonance spectroscopy imaging
por: Sun, Jubao, et al.
Publicado: (2017)

Lipidomic UPLC-MS/MS Profiles of Normal-Appearing White Matter Differentiate Primary and Secondary Progressive Multiple Sclerosis
por: Pousinis, Petros, et al.
Publicado: (2020)

Diffusion Tensor Imaging Revealed Microstructural Changes in Normal-Appearing White Matter Regions in Relapsing–Remitting Multiple Sclerosis
por: Bao, Jianfeng, et al.
Publicado: (2022)

Diffusion magnetic resonance imaging of normal-appearing white matter in multiple sclerosis: correlation with brain volume and clinical disability
por: Larassati, Hana, et al.
Publicado: (2022)

Plasma sphingolipids and depressive symptoms in coronary artery disease
por: Dinoff, Adam, et al.
Publicado: (2017)

Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age
por: Muñoz Maniega, Susana, et al.
Publicado: (2019)

Multimodal imaging findings in normal-appearing white matter of leucoaraiosis: a review
por: Zhong, Genlong, et al.
Publicado: (2016)

The association of diffusion tensor MRI measures of normal appearing white matter and cognition
por: Ng, Yi Lin, et al.
Publicado: (2023)

Magnetic resonance spectroscopy of normal appearing white matter in early relapsing-remitting multiple sclerosis: correlations between disability and spectroscopy
por: Ruiz-Peña, Juan Luis, et al.
Publicado: (2004)

Tissue Transglutaminase Appears in Monocytes and Macrophages but Not in Lymphocytes in White Matter Multiple Sclerosis Lesions
por: Chrobok, Navina L, et al.
Publicado: (2019)

Axon‐Myelin Unit Blistering as Early Event in MS Normal Appearing White Matter
por: Luchicchi, Antonio, et al.
Publicado: (2021)

Impaired toll-like receptor 8 signaling in multiple sclerosis
por: Johnson, Tory P, et al.
Publicado: (2013)

Diffusion-derived parameters in lesions, peri-lesion and normal-appearing white matter in multiple sclerosis using tensor, kurtosis and fixel-based analysis
por: van der Weijden, Chris WJ, et al.
Publicado: (2022)

Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation
por: van Horssen, Jack, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_0dg6m0onka6pkaufsjf3cvas2q