Aging Predisposes Oocytes to Meiotic Nondisjunction When the Cohesin Subunit SMC1 Is Reduced

In humans, meiotic chromosome segregation errors increase dramatically as women age, but the molecular defects responsible are largely unknown. Cohesion along the arms of meiotic sister chromatids provides an evolutionarily conserved mechanism to keep recombinant chromosomes associated until anaphas...

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Detalles Bibliográficos
Autores principales: Subramanian, Vijayalakshmi V., Bickel, Sharon E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577922/
https://www.ncbi.nlm.nih.gov/pubmed/19008956
http://dx.doi.org/10.1371/journal.pgen.1000263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577922/
https://www.ncbi.nlm.nih.gov/pubmed/19008956
http://dx.doi.org/10.1371/journal.pgen.1000263

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