AML1/ETO Oncoprotein Is Directed to AML1 Binding Regions and Co-Localizes with AML1 and HEB on Its Targets

A reciprocal translocation involving chromosomes 8 and 21 generates the AML1/ETO oncogenic transcription factor that initiates acute myeloid leukemia by recruiting co-repressor complexes to DNA. AML1/ETO interferes with the function of its wild-type counterpart, AML1, by directly targeting AML1 bind...

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Detalles Bibliográficos
Autores principales: Gardini, Alessandro, Cesaroni, Matteo, Luzi, Lucilla, Okumura, Akiko J., Biggs, Joseph R., Minardi, Simone P., Venturini, Elisa, Zhang, Dong-Er, Pelicci, Pier Giuseppe, Alcalay, Myriam
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577924/
https://www.ncbi.nlm.nih.gov/pubmed/19043539
http://dx.doi.org/10.1371/journal.pgen.1000275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2577924/
https://www.ncbi.nlm.nih.gov/pubmed/19043539
http://dx.doi.org/10.1371/journal.pgen.1000275

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