Low reduction potential of Ero1α regulatory disulphides ensures tight control of substrate oxidation

Formation of disulphide bonds within the mammalian endoplasmic reticulum (ER) requires the combined activities of Ero1α and protein disulphide isomerase (PDI). As Ero1α produces hydrogen peroxide during oxidation, regulation of its activity is critical in preventing ER-generated oxidative stress. He...

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Detalles Bibliográficos
Autores principales: Baker, Karl M, Chakravarthi, Seema, Langton, Kevin P, Sheppard, Alyson M, Lu, Hui, Bulleid, Neil J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579255/
https://www.ncbi.nlm.nih.gov/pubmed/18971943
http://dx.doi.org/10.1038/emboj.2008.230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579255/
https://www.ncbi.nlm.nih.gov/pubmed/18971943
http://dx.doi.org/10.1038/emboj.2008.230

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