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Epidemiology of Doublet/Multiplet Mutations in Lung Cancers: Evidence that a Subset Arises by Chronocoordinate Events

BACKGROUND: Evidence strongly suggests that spontaneous doublet mutations in normal mouse tissues generally arise from chronocoordinate events. These chronocoordinate mutations sometimes reflect “mutation showers”, which are multiple chronocoordinate mutations spanning many kilobases. However, littl...

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Detalles Bibliográficos
Autores principales: Chen, Zhenbin, Feng, Jinong, Buzin, Carolyn H., Sommer, Steve S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579325/
https://www.ncbi.nlm.nih.gov/pubmed/19005564
http://dx.doi.org/10.1371/journal.pone.0003714