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Estimating large-scale signaling networks through nested effect models with intervention effects from microarray data

Motivation: Targeted interventions using RNA interference in combination with the measurement of secondary effects with DNA microarrays can be used to computationally reverse engineer features of upstream non-transcriptional signaling cascades based on the nested structure of effects. Results: We ex...

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Detalles Bibliográficos
Autores principales: Fröhlich, Holger, Fellmann, Mark, Sültmann, Holger, Poustka, Annemarie, Beissbarth, Tim
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579711/
https://www.ncbi.nlm.nih.gov/pubmed/18227117
http://dx.doi.org/10.1093/bioinformatics/btm634