A Novel Assay to Trace Proliferation History In Vivo Reveals that Enhanced Divisional Kinetics Accompany Loss of Hematopoietic Stem Cell Self-Renewal

BACKGROUND: The maintenance of lifelong blood cell production ultimately rests on rare hematopoietic stem cells (HSCs) that reside in the bone marrow microenvironment. HSCs are traditionally viewed as mitotically quiescent relative to their committed progeny. However, traditional techniques for asse...

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Detalles Bibliográficos
Autores principales: Nygren, Jens M., Bryder, David
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2580029/
https://www.ncbi.nlm.nih.gov/pubmed/19002266
http://dx.doi.org/10.1371/journal.pone.0003710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2580029/
https://www.ncbi.nlm.nih.gov/pubmed/19002266
http://dx.doi.org/10.1371/journal.pone.0003710

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