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The LPS-Induced Transcriptional Upregulation of the Chicken Lysozyme Locus Involves CTCF Eviction and Noncoding RNA Transcription

Transcription of the lysozyme gene is rapidly induced by proinflammatory stimuli such as treatment with bacterial lipopolysaccharide (LPS). Here we show that this induction involves both the relief of repression mediated by the enhancer-blocking protein CTCF that binds to a negative regulatory eleme...

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Detalles Bibliográficos
Autores principales: Lefevre, Pascal, Witham, James, Lacroix, Claire E., Cockerill, Peter N., Bonifer, Constanze
Formato: Texto
Lenguaje:English
Publicado: Cell Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581490/
https://www.ncbi.nlm.nih.gov/pubmed/18851839
http://dx.doi.org/10.1016/j.molcel.2008.07.023