Iron-mediated Aggregation and a Localized Structural Change Characterize Ferritin from a Mutant Light Chain Polypeptide That Causes Neurodegeneration

Nucleotide insertions in the ferritin light chain (FTL) polypeptide gene cause hereditary ferritinopathy, a neurodegenerative disease characterized by abnormal accumulation of ferritin and iron in the central nervous system. Here we describe for the first time the protein structure and iron storage...

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Detalles Bibliográficos
Autores principales: Baraibar, Martin A., Barbeito, Ana G., Muhoberac, Barry B., Vidal, Ruben
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Protein Structure and Folding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581579/
https://www.ncbi.nlm.nih.gov/pubmed/18755684
http://dx.doi.org/10.1074/jbc.M805532200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581579/
https://www.ncbi.nlm.nih.gov/pubmed/18755684
http://dx.doi.org/10.1074/jbc.M805532200

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