Defining the in Vivo Role for Cytochrome b(5) in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochrome b(5)

In vitro, cytochrome b(5) modulates the rate of cytochrome P450-dependent mono-oxygenation reactions. However, the role of this enzyme in determining drug pharmacokinetics in vivo and the consequential effects on drug absorption distribution, metabolism, excretion, and toxicity are unclear. In order...

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Detalles Bibliográficos
Autores principales: Finn, Robert D., McLaughlin, Lesley A., Ronseaux, Sebastien, Rosewell, Ian, Houston, J. Brian, Henderson, Colin J., Wolf, C. Roland
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Enzyme Catalysis and Regulation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581580/
https://www.ncbi.nlm.nih.gov/pubmed/18805792
http://dx.doi.org/10.1074/jbc.M803496200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581580/
https://www.ncbi.nlm.nih.gov/pubmed/18805792
http://dx.doi.org/10.1074/jbc.M803496200

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