p16(INK4a)-induced senescence is disabled by melanoma-associated mutations

The p16(INK4a)-Rb tumour suppressor pathway is required for the initiation and maintenance of cellular senescence, a state of permanent growth arrest that acts as a natural barrier against cancer progression. Senescence can be overcome if the pathway is not fully engaged, and this may occur when p16...

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Detalles Bibliográficos
Autores principales: Haferkamp, Sebastian, Becker, Therese M, Scurr, Lyndee L, Kefford, Richard F, Rizos, Helen
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582406/
https://www.ncbi.nlm.nih.gov/pubmed/18843795
http://dx.doi.org/10.1111/j.1474-9726.2008.00422.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582406/
https://www.ncbi.nlm.nih.gov/pubmed/18843795
http://dx.doi.org/10.1111/j.1474-9726.2008.00422.x

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