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p16(INK4a)-induced senescence is disabled by melanoma-associated mutations
The p16(INK4a)-Rb tumour suppressor pathway is required for the initiation and maintenance of cellular senescence, a state of permanent growth arrest that acts as a natural barrier against cancer progression. Senescence can be overcome if the pathway is not fully engaged, and this may occur when p16...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582406/ https://www.ncbi.nlm.nih.gov/pubmed/18843795 http://dx.doi.org/10.1111/j.1474-9726.2008.00422.x |