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Detecting Clusters of Mutations

Positive selection for protein function can lead to multiple mutations within a small stretch of DNA, i.e., to a cluster of mutations. Recently, Wagner proposed a method to detect such mutation clusters. His method, however, did not take into account that residues with high solvent accessibility are...

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Detalles Bibliográficos
Autores principales: Zhou, Tong, Enyeart, Peter J., Wilke, Claus O.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582452/
https://www.ncbi.nlm.nih.gov/pubmed/19018282
http://dx.doi.org/10.1371/journal.pone.0003765