Improved cell-penetrating peptide–PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle

Steric blocking peptide nucleic acid (PNA) oligonucleotides have been used increasingly for redirecting RNA splicing particularly in therapeutic applications such as Duchenne muscular dystrophy (DMD). Covalent attachment of a cell-penetrating peptide helps to improve cell delivery of PNA. We have us...

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Detalles Bibliográficos
Autores principales: Ivanova, Gabriela D., Arzumanov, Andrey, Abes, Rachida, Yin, Haifang, Wood, Matthew J. A., Lebleu, Bernard, Gait, Michael J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582604/
https://www.ncbi.nlm.nih.gov/pubmed/18842625
http://dx.doi.org/10.1093/nar/gkn671

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582604/
https://www.ncbi.nlm.nih.gov/pubmed/18842625
http://dx.doi.org/10.1093/nar/gkn671

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