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Role of the UPS in Liddle syndrome
Hypertension is a serious medical problem affecting a large population worldwide. Liddle syndrome is a hereditary form of early onset hypertension caused by mutations in the epithelial Na(+ )channel (ENaC). The mutated region, called the PY (Pro-Pro-x-Tyr) motif, serves as a binding site for Nedd4-2...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582799/ https://www.ncbi.nlm.nih.gov/pubmed/19007435 http://dx.doi.org/10.1186/1471-2091-9-S1-S5 |