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Caspase-8 goes cardiolipin: a new platform to provide mitochondria with microdomains of apoptotic signals?
In certain cell types, apoptosis in response to extracellular stimuli like Fas depends on a mitochondrial amplificatory loop: the apical caspase-8 cleaves and activates the BH3-only member of the Bcl-2 family BID. In turn, BID induces the release of cytochrome c from mitochondria to the cytoplasm, w...
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| Formato: | Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582901/ https://www.ncbi.nlm.nih.gov/pubmed/19001131 http://dx.doi.org/10.1083/jcb.200810125 |