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Non-Native R1 Substitution in the S4 Domain Uniquely Alters Kv4.3 Channel Gating
The S4 transmembrane domain in Shaker (Kv1) voltage-sensitive potassium channels has four basic residues (R1–R4) that are responsible for carrying the majority of gating charge. In Kv4 channels, however, R1 is replaced by a neutral valine at position 287. Among other differences, Kv4 channels displa...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582947/ https://www.ncbi.nlm.nih.gov/pubmed/19020667 http://dx.doi.org/10.1371/journal.pone.0003773 |