Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

Focal Adhesion Kinase (FAK) is a non-receptor tyrosine kinase required for cell migration, proliferation and survival. FAK overexpression has been documented in diverse human cancers and is associated with a poor clinical outcome. Recently, a novel bis-anilino pyrimidine inhibitor, TAE226, was repor...

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Detalles Bibliográficos
Autores principales: Lietha, Daniel, Eck, Michael J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582962/
https://www.ncbi.nlm.nih.gov/pubmed/19030106
http://dx.doi.org/10.1371/journal.pone.0003800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582962/
https://www.ncbi.nlm.nih.gov/pubmed/19030106
http://dx.doi.org/10.1371/journal.pone.0003800

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