A Point Mutation in Translation Initiation Factor 2B Leads to a Continuous Hyper Stress State in Oligodendroglial-Derived Cells

BACKGROUND: Mutations in eukaryotic translation initiation factor 2B (eIF2B) cause Childhood Ataxia with CNS Hypomyelination (CACH), also known as Vanishing White Matter disease (VWM). The disease is manifested by loss of brain myelin upon physiological stress. In a previous study, we showed that fi...

Descripción completa

Detalles Bibliográficos
Autores principales: Kantor, Liraz, Pinchasi, Dalia, Mintz, Michelle, Hathout, Yetrib, Vanderver, Adeline, Elroy-Stein, Orna
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583043/
https://www.ncbi.nlm.nih.gov/pubmed/19023445
http://dx.doi.org/10.1371/journal.pone.0003783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583043/
https://www.ncbi.nlm.nih.gov/pubmed/19023445
http://dx.doi.org/10.1371/journal.pone.0003783

Ejemplares similares