Chemical–Genetic Profiling of Imidazo[1,2-a]pyridines and -Pyrimidines Reveals Target Pathways Conserved between Yeast and Human Cells

Small molecules have been shown to be potent and selective probes to understand cell physiology. Here, we show that imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines compose a class of compounds that target essential, conserved cellular processes. Using validated chemogenomic assays in Saccharom...

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Detalles Bibliográficos
Autores principales: Yu, Lisa, Lopez, Andres, Anaflous, Abderrahmane, El Bali, Brahim, Hamal, Abdellah, Ericson, Elke, Heisler, Lawrence E., McQuibban, Angus, Giaever, Guri, Nislow, Corey, Boone, Charles, Brown, Grant W., Bellaoui, Mohammed
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583946/
https://www.ncbi.nlm.nih.gov/pubmed/19043571
http://dx.doi.org/10.1371/journal.pgen.1000284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583946/
https://www.ncbi.nlm.nih.gov/pubmed/19043571
http://dx.doi.org/10.1371/journal.pgen.1000284

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