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Formation and Growth of Oligomers: A Monte Carlo Study of an Amyloid Tau Fragment
Small oligomers formed early in the process of amyloid fibril formation may be the major toxic species in Alzheimer's disease. We investigate the early stages of amyloid aggregation for the tau fragment AcPHF6 (Ac-VQIVYK-NH2) using an implicit solvent all-atom model and extensive Monte Carlo si...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583953/ https://www.ncbi.nlm.nih.gov/pubmed/19057640 http://dx.doi.org/10.1371/journal.pcbi.1000238 |