Human activated protein C variants in a rat model of arterial thrombosis

BACKGROUND: Activated protein C (APC) inhibits coagulation by degrading activated factor V (FVa) and factor VIII (FVIIIa), protein S (PS) functioning as a cofactor to APC. METHODS: By mutagenesis of the vitamin K-dependent Gla domain of APC, we have recently created an APC variant having enhanced an...

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Detalles Bibliográficos
Autores principales: Malm, Karl, Arnljots, Björn, Dahlbäck, Björn
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Original Basic Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584025/
https://www.ncbi.nlm.nih.gov/pubmed/18957140
http://dx.doi.org/10.1186/1477-9560-6-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584025/
https://www.ncbi.nlm.nih.gov/pubmed/18957140
http://dx.doi.org/10.1186/1477-9560-6-16

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