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Human activated protein C variants in a rat model of arterial thrombosis

BACKGROUND: Activated protein C (APC) inhibits coagulation by degrading activated factor V (FVa) and factor VIII (FVIIIa), protein S (PS) functioning as a cofactor to APC. METHODS: By mutagenesis of the vitamin K-dependent Gla domain of APC, we have recently created an APC variant having enhanced an...

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Detalles Bibliográficos
Autores principales:	Malm, Karl, Arnljots, Björn, Dahlbäck, Björn
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Original Basic Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584025/ https://www.ncbi.nlm.nih.gov/pubmed/18957140 http://dx.doi.org/10.1186/1477-9560-6-16

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