Fatty Acid Synthase Inhibitors Modulate Energy Balance via Mammalian Target of Rapamycin Complex 1 Signaling in the Central Nervous System

OBJECTIVE—Evidence links the hypothalamic fatty acid synthase (FAS) pathway to the regulation of food intake and body weight. This includes pharmacological inhibitors that potently reduce feeding and body weight. The mammalian target of rapamycin (mTOR) is an intracellular fuel sensor whose activity...

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Detalles Bibliográficos
Autores principales: Proulx, Karine, Cota, Daniela, Woods, Stephen C., Seeley, Randy J.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584128/
https://www.ncbi.nlm.nih.gov/pubmed/18776140
http://dx.doi.org/10.2337/db07-1690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584128/
https://www.ncbi.nlm.nih.gov/pubmed/18776140
http://dx.doi.org/10.2337/db07-1690

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