Lower Metabolic Rate in Individuals Heterozygous for Either a Frameshift or a Functional Missense MC4R Variant

OBJECTIVE—Humans with functional variants in the melanocortin 4 receptor (MC4R) are obese, hyperphagic, and hyperinsulinemic but have been reported to have no difference in energy expenditure. RESEARCH DESIGN AND METHODS—We investigated the association of two MC4R variants, Arg165Gln (R165Q) and A i...

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Detalles Bibliográficos
Autores principales: Krakoff, Jonathan, Ma, Lijun, Kobes, Sayuko, Knowler, William C., Hanson, Robert L., Bogardus, Clifton, Baier, Leslie J.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584132/
https://www.ncbi.nlm.nih.gov/pubmed/18835933
http://dx.doi.org/10.2337/db08-0577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584132/
https://www.ncbi.nlm.nih.gov/pubmed/18835933
http://dx.doi.org/10.2337/db08-0577

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