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AICAR decreases the activity of two distinct amiloride-sensitive Na(+)-permeable channels in H441 human lung epithelial cell monolayers
Transepithelial transport of Na(+) across the lung epithelium via amiloride-sensitive Na(+) channels (ENaC) regulates fluid volume in the lung lumen. Activators of AMP-activated protein kinase (AMPK), the adenosine monophosphate mimetic AICAR, and the biguanide metformin decreased amiloride-sensitiv...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Physiological Society
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584878/ https://www.ncbi.nlm.nih.gov/pubmed/18723760 http://dx.doi.org/10.1152/ajplung.90353.2008 |