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Development of selective blockers for Ca(2+)-activated Cl(- )channel using Xenopus laevis oocytes with an improved drug screening strategy
BACKGROUND: Ca(2+)-activated Cl(- )channels (CaCCs) participate in many important physiological processes. However, the lack of effective and selective blockers has hindered the study of these channels, mostly due to the lack of good assay system. Here, we have developed a reliable drug screening me...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585076/ https://www.ncbi.nlm.nih.gov/pubmed/18959787 http://dx.doi.org/10.1186/1756-6606-1-14 |