Heterozygous expression of myocilin glaucoma mutants increases secretion of the mutant forms and reduces extracellular processed myocilin

PURPOSE: Heterozygous mutations in the myocilin gene (MYOC) cause glaucoma by an unknown mechanism. MYOC encodes an extracellular protein of unidentified function that undergoes intracellular endoproteolytic processing in the secretory pathway. It has been described that co-expression of wild-type/m...

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Detalles Bibliográficos
Autores principales: Aroca-Aguilar, José-Daniel, Sánchez-Sánchez, Francisco, Martínez-Redondo, Francisco, Coca-Prados, Miguel, Escribano, Julio
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585175/
https://www.ncbi.nlm.nih.gov/pubmed/19023451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585175/
https://www.ncbi.nlm.nih.gov/pubmed/19023451

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