CTLA-4 Activation of Phosphatidylinositol 3-Kinase (PI 3-K) and Protein Kinase B (PKB/AKT) Sustains T-Cell Anergy without Cell Death

The balance of T-cell proliferation, anergy and apoptosis is central to immune function. In this regard, co-receptor CTLA-4 is needed for the induction of anergy and tolerance. One central question concerns the mechanism by which CTLA-4 can induce T-cell non-responsiveness without a concurrent induc...

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Detalles Bibliográficos
Autores principales: Schneider, Helga, Valk, Elke, Leung, Rufina, Rudd, Christopher E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585791/
https://www.ncbi.nlm.nih.gov/pubmed/19052636
http://dx.doi.org/10.1371/journal.pone.0003842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585791/
https://www.ncbi.nlm.nih.gov/pubmed/19052636
http://dx.doi.org/10.1371/journal.pone.0003842

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