Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1

Mutations resulting in overexpression of intracellular Notch1 (ICN1) are frequently observed in human T cell acute lymphoblastic leukemia (T-ALL). We have determined the consequences of ICN1 overexpression from retroviral vectors introduced into bone marrow cells. Early consequences are the generati...

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Detalles Bibliográficos
Autores principales: Li, Xiaoyu, Gounari, Fotini, Protopopov, Alexei, Khazaie, Khashayarsha, von Boehmer, Harald
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585834/
https://www.ncbi.nlm.nih.gov/pubmed/18981238
http://dx.doi.org/10.1084/jem.20081561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585834/
https://www.ncbi.nlm.nih.gov/pubmed/18981238
http://dx.doi.org/10.1084/jem.20081561

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