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Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
Mutations resulting in overexpression of intracellular Notch1 (ICN1) are frequently observed in human T cell acute lymphoblastic leukemia (T-ALL). We have determined the consequences of ICN1 overexpression from retroviral vectors introduced into bone marrow cells. Early consequences are the generati...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585834/ https://www.ncbi.nlm.nih.gov/pubmed/18981238 http://dx.doi.org/10.1084/jem.20081561 |