B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency

CD45 and Fas regulate tyrosine phosphorylation and apoptotic signaling pathways, respectively. Mutation of an inhibitory wedge motif in CD45 (E613R) results in hyperresponsive thymocytes and B cells on the C57BL/6 background, but no overt autoimmunity, whereas Fas deletion results in a mild autoimmu...

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Detalles Bibliográficos
Autores principales: Gupta, Vikas A., Hermiston, Michelle L., Cassafer, Gail, Daikh, David I., Weiss, Arthur
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585841/
https://www.ncbi.nlm.nih.gov/pubmed/19001138
http://dx.doi.org/10.1084/jem.20081204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585841/
https://www.ncbi.nlm.nih.gov/pubmed/19001138
http://dx.doi.org/10.1084/jem.20081204

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