Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

Neuritic plaques in the brains are one of the pathological hallmarks of Alzheimer's disease (AD). Amyloid β-protein (Aβ), the central component of neuritic plaques, is derived from β-amyloid precursor protein (APP) after β- and γ-secretase cleavage. The molecular mechanism underlying the pathog...

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Detalles Bibliográficos
Autores principales: Qing, Hong, He, Guiqiong, Ly, Philip T. T., Fox, Christopher J., Staufenbiel, Matthias, Cai, Fang, Zhang, Zhuohua, Wei, Shengcai, Sun, Xiulian, Chen, Chia-Hsiung, Zhou, Weihui, Wang, Ke, Song, Weihong
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585842/
https://www.ncbi.nlm.nih.gov/pubmed/18955571
http://dx.doi.org/10.1084/jem.20081588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585842/
https://www.ncbi.nlm.nih.gov/pubmed/18955571
http://dx.doi.org/10.1084/jem.20081588

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