Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

Progressive loss of T cell functionality is a hallmark of chronic infection with human immunodeficiency virus 1 (HIV-1). We have identified a novel population of dysfunctional T cells marked by surface expression of the glycoprotein Tim-3. The frequency of this population was increased in HIV-1–infe...

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Detalles Bibliográficos
Autores principales: Jones, R. Brad, Ndhlovu, Lishomwa C., Barbour, Jason D., Sheth, Prameet M., Jha, Aashish R., Long, Brian R., Wong, Jessica C., Satkunarajah, Malathy, Schweneker, Marc, Chapman, Joan M., Gyenes, Gabor, Vali, Bahareh, Hyrcza, Martin D., Yue, Feng Yun, Kovacs, Colin, Sassi, Aref, Loutfy, Mona, Halpenny, Roberta, Persad, Desmond, Spotts, Gerald, Hecht, Frederick M., Chun, Tae-Wook, McCune, Joseph M., Kaul, Rupert, Rini, James M., Nixon, Douglas F., Ostrowski, Mario A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585847/
https://www.ncbi.nlm.nih.gov/pubmed/19001139
http://dx.doi.org/10.1084/jem.20081398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585847/
https://www.ncbi.nlm.nih.gov/pubmed/19001139
http://dx.doi.org/10.1084/jem.20081398

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