Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE(2) and LXA(4) in the induction of macrophage death

Virulent Mycobacterium tuberculosis (Mtb) induces a maladaptive cytolytic death modality, necrosis, which is advantageous for the pathogen. We report that necrosis of macrophages infected with the virulent Mtb strains H37Rv and Erdmann depends on predominant LXA(4) production that is part of the ant...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Minjian, Divangahi, Maziar, Gan, Huixian, Shin, Daniel S.J., Hong, Song, Lee, David M., Serhan, Charles N., Behar, Samuel M., Remold, Heinz G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585850/
https://www.ncbi.nlm.nih.gov/pubmed/18955568
http://dx.doi.org/10.1084/jem.20080767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585850/
https://www.ncbi.nlm.nih.gov/pubmed/18955568
http://dx.doi.org/10.1084/jem.20080767

Ejemplares similares