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The Janus-Faced Nature of the C(2)B Domain Is Fundamental for Synaptotagmin-1 Function
Synaptotagmin-1 functions as a Ca(2+) sensor in neurotransmitter release, and was proposed to act on both the synaptic vesicle and plasma membranes through interactions involving the Ca(2+)-binding top loops of its C(2) domains and the Ca(2+)-independent bottom face of the C(2)B domain. However, the...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587052/ https://www.ncbi.nlm.nih.gov/pubmed/18953334 http://dx.doi.org/10.1038/nsmb.1508 |