Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8’s E1

[Image: see text] Post-translational covalent modification by ubiquitin and ubiquitin-like proteins (UBLs) is a major eukaryotic mechanism for regulating protein function. In general, each UBL has its own E1 that serves as the entry point for a cascade. The E1 first binds the UBL and catalyzes adeny...

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Detalles Bibliográficos
Autores principales: Souphron, Judith, Waddell, M. Brett, Paydar, Amir, Tokgöz-Gromley, Zeynep, Roussel, Martine F., Schulman, Brenda A.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587436/
https://www.ncbi.nlm.nih.gov/pubmed/18652489
http://dx.doi.org/10.1021/bi800604c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587436/
https://www.ncbi.nlm.nih.gov/pubmed/18652489
http://dx.doi.org/10.1021/bi800604c

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