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Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8’s E1
[Image: see text] Post-translational covalent modification by ubiquitin and ubiquitin-like proteins (UBLs) is a major eukaryotic mechanism for regulating protein function. In general, each UBL has its own E1 that serves as the entry point for a cascade. The E1 first binds the UBL and catalyzes adeny...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587436/ https://www.ncbi.nlm.nih.gov/pubmed/18652489 http://dx.doi.org/10.1021/bi800604c |