Elucidation of the mode of interaction in the UP1–telomerase RNA–telomeric DNA ternary complex which serves to recruit telomerase to telomeric DNA and to enhance the telomerase activity

We found that UP1, a proteolytic product of heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1), both enhances and represses the telomerase activity. The formation of the UP1–telomerase RNA–telomeric DNA ternary complex was revealed by a gel retardation experiment. The interactions in the ternary...

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Detalles Bibliográficos
Autores principales: Nagata, Takashi, Takada, Yusuke, Ono, Asami, Nagata, Kayoko, Konishi, Yuki, Nukina, Takeshi, Ono, Manami, Matsugami, Akimasa, Furukawa, Ayako, Fujimoto, Natsuki, Fukuda, Hirokazu, Nakagama, Hitoshi, Katahira, Masato
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588520/
https://www.ncbi.nlm.nih.gov/pubmed/18953025
http://dx.doi.org/10.1093/nar/gkn767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588520/
https://www.ncbi.nlm.nih.gov/pubmed/18953025
http://dx.doi.org/10.1093/nar/gkn767

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