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Association Rate Constants of Ras-Effector Interactions Are Evolutionarily Conserved

Evolutionary conservation of protein interaction properties has been shown to be a valuable indication for functional importance. Here we use homology interface modeling of 10 Ras-effector complexes by selecting ortholog proteins from 12 organisms representing the major eukaryotic branches, except p...

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Detalles Bibliográficos
Autores principales: Kiel, Christina, Aydin, Dorothee, Serrano, Luis
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588540/
https://www.ncbi.nlm.nih.gov/pubmed/19096503
http://dx.doi.org/10.1371/journal.pcbi.1000245