Methylation of WTH3, a possible drug resistant gene, inhibits p53 regulated expression

BACKGROUND: Previous results showed that over-expression of the WTH3 gene in MDR cells reduced MDR1 gene expression and converted their resistance to sensitivity to various anticancer drugs. In addition, the WTH3 gene promoter was hypermethylated in the MCF7/AdrR cell line and primary drug resistant...

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Detalles Bibliográficos
Autores principales: Tian, Kegui, Wang, Yuezeng, Huang, Yu, Sun, Boqiao, Li, Yuxin, Xu, Haopeng
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588621/
https://www.ncbi.nlm.nih.gov/pubmed/18992151
http://dx.doi.org/10.1186/1471-2407-8-327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588621/
https://www.ncbi.nlm.nih.gov/pubmed/18992151
http://dx.doi.org/10.1186/1471-2407-8-327

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