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Methylation of WTH3, a possible drug resistant gene, inhibits p53 regulated expression
BACKGROUND: Previous results showed that over-expression of the WTH3 gene in MDR cells reduced MDR1 gene expression and converted their resistance to sensitivity to various anticancer drugs. In addition, the WTH3 gene promoter was hypermethylated in the MCF7/AdrR cell line and primary drug resistant...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2588621/ https://www.ncbi.nlm.nih.gov/pubmed/18992151 http://dx.doi.org/10.1186/1471-2407-8-327 |