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The pharmacologic basis for the efficacy of high-dose Ara-C and sequential asparaginase in adult acute myelogenous leukemia.

Dose-related effects of ara-C include overcoming a relative transport impediment in human leukemia cells. This result then allows intracellular metabolism and incorporation into DNA to proceed to the maximum extent possible. In addition, the increased synthesis of ara-CDP-choline associated with the...

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Detalles Bibliográficos
Autores principales: Capizzi, R. L., White, C.
Formato: Texto
Lenguaje:English
Publicado: Yale Journal of Biology and Medicine 1988
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2590410/
https://www.ncbi.nlm.nih.gov/pubmed/3163212