Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death

When exposed to tumor necrosis factor (TNF) or TNF-related apoptosis-inducing ligand (TRAIL), a closely related death ligand and investigational therapeutic, cells enter a protracted period of variable duration in which only upstream initiator caspases are active. A subsequent and sudden transition...

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Detalles Bibliográficos
Autores principales: Albeck, John G, Burke, John M, Spencer, Sabrina L, Lauffenburger, Douglas A, Sorger, Peter K
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592357/
https://www.ncbi.nlm.nih.gov/pubmed/19053173
http://dx.doi.org/10.1371/journal.pbio.0060299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2592357/
https://www.ncbi.nlm.nih.gov/pubmed/19053173
http://dx.doi.org/10.1371/journal.pbio.0060299

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